Nonsteroidal Anti-inflammatory Drugs (NSAIDs) NSAIDs include both prescription and over-the-counter medicine. They are often used to relieve pain or reduce inflammation from conditions such as arthritis. However, NSAIDs can make your body retain fluid and decrease the function of your kidneys. This may cause your blood pressure to rise even higher. The extra fluid and higher blood pressure puts an added burden on your heart. [JPR1] The use of NSAIDS also can increase your risk for heart attack or stroke, particularly is used in high doses.